Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | PKM | P14618 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933157 | 0.88 | MAPT (0.52) | POLBMAPTPKMSMN1; SMN2NPC1 | |
| SCHEMBL7942303 | 0.81 | NPC1 (0.53) | MAPTSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL7942306 | 0.79 | MEN1 (0.51) | MAPTPKMSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7940427 | 0.76 | SMN1; SMN2 (0.48) | POLBMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7942653 | 0.74 | BACE1 (0.46) | SMN1; SMN2NPC1RAB9ABACE1 | |
| SCHEMBL16015428 | 0.73 | PLK1 (0.40) | RAB9A | |
| SCHEMBL7942651 | 0.73 | BACE1 (0.47) | SMN1; SMN2NPC1RAB9ABACE1 | |
| SCHEMBL20109473 | 0.72 | MTNR1A (0.39) | RAB9A | |
| SCHEMBL8027585 | 0.72 | MPO (0.50) | POLBMAPTSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL7933959 | 0.71 | BACE1 (0.48) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |