Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953632 | 0.87 | HRH4 (0.54) | HRH4KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8818586 | 0.87 | TMEM97 (0.50) | HRH4ALDH1A1MEN1GAAKMT2A | |
| SCHEMBL7949983 | 0.86 | HTR1A (0.43) | HRH4ALDH1A1MEN1LMNAGAA | |
| SCHEMBL7953606 | 0.84 | OPRL1 (0.50) | HRH4ALDH1A1GAAMAPT | |
| SCHEMBL7953556 | 0.83 | TMEM97 (0.45) | HRH4ALDH1A1RAB9ANPC1GAA | |
| SCHEMBL7943407 | 0.83 | MMP9 (0.50) | HRH4ALDH1A1MEN1LMNAGAA | |
| SCHEMBL7943360 | 0.83 | HRH4 (0.56) | HRH4KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL7951610 | 0.82 | HTR1A (0.44) | ALDH1A1HPGDMEN1GAAMAPT | |
| SCHEMBL7949893 | 0.82 | MMP12 (0.50) | HRH4 | |
| SCHEMBL7951116 | 0.82 | HRH4 (0.55) | HRH4KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | disclosed |