Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GOT1 | P17174 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949983 | 0.90 | HTR1A (0.43) | HRH4MEN1KMT2AHTR1AHTR1D | |
| SCHEMBL8818586 | 0.90 | TMEM97 (0.50) | MMP9MMP1MMP2MMP12HRH4 | |
| SCHEMBL7943428 | 0.90 | MAPK1 (0.52) | MEN1KMT2AHTR1AHTR1DHTR1B | |
| SCHEMBL7953606 | 0.89 | OPRL1 (0.50) | MMP9MMP1MMP2MMP12HRH4 | |
| SCHEMBL7951610 | 0.89 | HTR1A (0.44) | DRD2DRD3MEN1KMT2AHTR1A | |
| SCHEMBL7953556 | 0.88 | TMEM97 (0.45) | MMP9MMP1MMP2MMP12HRH4 | |
| SCHEMBL7949893 | 0.87 | MMP12 (0.50) | MMP1MMP12HRH4GOT1HTR1A | |
| SCHEMBL7951679 | 0.83 | DRD2 (0.53) | HRH4DRD2DRD3MEN1KMT2A | |
| SCHEMBL7943312 | 0.83 | HRH4 (0.48) | HRH4MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7953632 | 0.82 | HRH4 (0.54) | HRH4DRD2DRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | claimed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | claimed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | claimed |
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | disclosed |