Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8818586 | 0.91 | TMEM97 (0.50) | MMP2MMP1MMP9MMP12HRH4 | |
| SCHEMBL7953556 | 0.89 | TMEM97 (0.45) | MMP2MMP1MMP9MMP12HRH4 | |
| SCHEMBL7943407 | 0.89 | MMP9 (0.50) | MMP2MMP1MMP9MMP12HRH4 | |
| SCHEMBL7949893 | 0.87 | MMP12 (0.50) | MMP1MMP12HRH4TMEM97SIGMAR1 | |
| SCHEMBL7949983 | 0.87 | HTR1A (0.43) | HRH4TMEM97SIGMAR1GAAMAPT | |
| SCHEMBL7943428 | 0.87 | MAPK1 (0.52) | TMEM97SIGMAR1GAAMAPTALDH1A1 | |
| SCHEMBL7951610 | 0.86 | HTR1A (0.44) | GAAMAPTALDH1A1TSHR | |
| SCHEMBL7943312 | 0.84 | HRH4 (0.48) | HRH4GAAMAPTALDH1A1 | |
| SCHEMBL7951589 | 0.82 | KMT2A (0.51) | OPRL1HRH4NPBWR1MCHR1MAPT | |
| SCHEMBL7953632 | 0.81 | HRH4 (0.54) | HRH4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | claimed |
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | disclosed |