Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GFER | P55789 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647236 | 0.84 | ADRB1 (0.52) | MAPTKDM4EALDH1A1HTR2AHTR2C | |
| SCHEMBL7940843 | 0.83 | HTR2B (0.36) | KMT2AHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL4487460 | 0.83 | ADRB1 (0.50) | MAPTKMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL746788 | 0.82 | ADRB1 (0.47) | ALDH1A1KMT2AHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6374876 | 0.81 | ADRB1 (0.49) | MAPTKMT2AHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6830556 | 0.81 | ADRB1 (0.46) | ALDH1A1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL3017728 | 0.80 | ADRB1 (0.56) | MAPTKDM4EALDH1A1KMT2AHTR2A | |
| SCHEMBL22914744 | 0.80 | POLB (0.46) | KDM4EALDH1A1HTR2AHTR2CHTR2B | |
| SCHEMBL19003593 | 0.80 | MGLL (0.39) | MAPTKDM4EALDH1A1KMT2AHTR2A | |
| SCHEMBL38662505 | 0.79 | ADRB2 (0.50) | ALDH1A1HTR2AHTR2CHTR2BUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019392-A1 | PURINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME CORP. (US) | 2010-02-18 | — | — | WO | disclosed |