Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951892 | 0.90 | POLB (0.39) | HTTALDH1A1HPGDPOLBNPC1 | |
| SCHEMBL7948016 | 0.87 | POLB (0.38) | HTTALDH1A1POLBMMP3NPC1 | |
| SCHEMBL7969063 | 0.87 | CYP2D6 (0.42) | ALDH1A1HPGDPOLB | |
| SCHEMBL7945520 | 0.86 | NPC1 (0.39) | ALDH1A1HPGDPOLBMTNR1AMTNR1B | |
| SCHEMBL7982206 | 0.85 | POLB (0.36) | HTTALDH1A1HPGDPOLBMMP3 | |
| SCHEMBL7951886 | 0.85 | MITF (0.45) | HTTALDH1A1HPGDPOLBNPC1 | |
| SCHEMBL7947062 | 0.85 | MITF (0.43) | HTTALDH1A1HPGDPOLBNPC1 | |
| SCHEMBL7947094 | 0.85 | POLB (0.37) | HTTALDH1A1POLBMMP3MMP1 | |
| SCHEMBL7946743 | 0.85 | MITF (0.45) | HTTALDH1A1HPGDPOLBNPC1 | |
| SCHEMBL7947164 | 0.85 | PLA2G2A (0.37) | ALDH1A1POLBNPC1RAB9AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |