Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | AHCY | P23526 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938408 | 0.94 | CYP2C9 (0.43) | KDM4EPOLBKMT2AGAAALDH1A1 | |
| SCHEMBL7937735 | 0.89 | KMT2A (0.41) | POLBKMT2AGAAALDH1A1 | |
| SCHEMBL7951892 | 0.89 | POLB (0.39) | POLBPAX8MITFALDH1A1HPGD | |
| SCHEMBL7944071 | 0.87 | HTT (0.40) | POLBALDH1A1HPGD | |
| SCHEMBL7937873 | 0.86 | HTR2A (0.41) | KDM4EPOLBKMT2AALDH1A1MAPT | |
| SCHEMBL7948016 | 0.86 | POLB (0.38) | KDM4EPOLBKMT2APAX8MITF | |
| SCHEMBL7992668 | 0.86 | SIGMAR1 (0.45) | TSHR | |
| SCHEMBL7945520 | 0.85 | NPC1 (0.39) | KDM4EPOLBKMT2AALDH1A1MAPT | |
| SCHEMBL7982206 | 0.85 | POLB (0.36) | POLBKMT2APAX8MITFALDH1A1 | |
| SCHEMBL7946743 | 0.84 | MITF (0.45) | CYP2D6KDM4EPOLBKMT2APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |