Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948016 | 0.88 | POLB (0.38) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL7951892 | 0.88 | POLB (0.39) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL7947062 | 0.86 | MITF (0.43) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL7946743 | 0.86 | MITF (0.45) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL7947094 | 0.86 | POLB (0.37) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL7951886 | 0.86 | MITF (0.45) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL7944071 | 0.85 | HTT (0.40) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL7969063 | 0.85 | CYP2D6 (0.42) | POLBALDH1A1HPGDMITFPAX8 | |
| SCHEMBL7947164 | 0.84 | PLA2G2A (0.37) | POLBNPC1RAB9AALDH1A1EPHX2 | |
| SCHEMBL7945520 | 0.84 | NPC1 (0.39) | POLBNPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |