Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945520 | 0.91 | NPC1 (0.39) | POLBALDH1A1HPGDEPHX2NPC1 | |
| SCHEMBL7979470 | 0.90 | MAPK1 (0.36) | ALDH1A1MAPK1NPC1RAB9AAPLNR | |
| SCHEMBL7944071 | 0.90 | HTT (0.40) | POLBHTTALDH1A1HPGDEPHX2 | |
| SCHEMBL7948016 | 0.89 | POLB (0.38) | POLBHTTMITFOPRK1PAX8 | |
| SCHEMBL7969063 | 0.89 | CYP2D6 (0.42) | POLBMITFPAX8ALDH1A1HPGD | |
| SCHEMBL7982206 | 0.88 | POLB (0.36) | POLBHTTMITFOPRK1PAX8 | |
| SCHEMBL7946743 | 0.87 | MITF (0.45) | POLBHTTMITFOPRK1PAX8 | |
| SCHEMBL7951886 | 0.87 | MITF (0.45) | POLBHTTMITFOPRK1PAX8 | |
| SCHEMBL7947094 | 0.87 | POLB (0.37) | POLBHTTMITFOPRK1PAX8 | |
| SCHEMBL7947062 | 0.87 | MITF (0.43) | POLBHTTMITFOPRK1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |