Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7939410 | 0.84 | ALDH1A1 (0.38) | MAPTTP53ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7941017 | 0.82 | MAPK1 (0.47) | MAPTTP53ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3236783 | 0.81 | GUCY1B2 (0.43) | SMN1; SMN2 | |
| SCHEMBL7934714 | 0.80 | MAPT (0.36) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7940603 | 0.77 | CD274 (0.35) | MRGPRX4KMT2A | |
| SCHEMBL3231416 | 0.75 | GUCY1B2 (0.46) | — | |
| SCHEMBL3236218 | 0.75 | GUCY1B2 (0.38) | — | |
| SCHEMBL3620263 | 0.75 | GUCY1B2 (0.41) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7940148 | 0.73 | CD274 (0.35) | TP53SMN1; SMN2KDM4ECCR5 | |
| SCHEMBL3239269 | 0.73 | MAPT (0.42) | MAPTTP53ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |