Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938346 | 0.88 | ALDH1A1 (0.38) | ADORA2AALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL7945987 | 0.84 | TYRO3 (0.36) | ALDH1A1LMNAHSD17B10AKT1MTOR | |
| SCHEMBL7944716 | 0.82 | CYP1A2 (0.39) | ALDH1A1LMNAHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7947006 | 0.81 | ALDH1A1 (0.34) | ADORA2AADORA1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL7944000 | 0.77 | ALDH1A1 (0.33) | ADORA2AADORA1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL3227759 | 0.72 | ALDH1A1 (0.39) | ADORA2AADORA1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL7937737 | 0.72 | ALDH1A1 (0.37) | ADORA2AADORA1ALDH1A1LMNAMAPT | |
| SCHEMBL7937747 | 0.72 | HSF1 (0.35) | ADORA2AADORA1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL3227758 | 0.72 | CYP1A2 (0.41) | ADORA2AADORA1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL7943995 | 0.69 | HSF1 (0.36) | ADORA2AADORA1ALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008775-A1 | AMINOPYRIDOPYRAZINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |