Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957597 | 0.77 | HPGD (0.37) | RAB9ASMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL7955658 | 0.77 | MEN1 (0.35) | RAB9ASMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL7946462 | 0.76 | CYP11B2 (0.36) | RAB9AHPGDALDH1A1HSD17B10MEN1 | |
| SCHEMBL10744080 | 0.76 | MKNK1 (0.46) | KMT2A | |
| SCHEMBL8329574 | 0.74 | PTPN11 (0.33) | RAB9ASMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL8330014 | 0.67 | SMN1; SMN2 (0.43) | RAB9ASMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL30680438 | 0.65 | SMN1; SMN2 (0.68) | RAB9ASMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL38770 | 0.65 | SMN1; SMN2 (0.68) | RAB9ASMN1; SMN2LMNAHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL5008498 | 0.64 | SMN1; SMN2 (0.66) | RAB9ASMN1; SMN2LMNAHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL28905020 | 0.64 | SMN1; SMN2 (0.66) | RAB9ASMN1; SMN2LMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |