Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957597 | 0.79 | HPGD (0.37) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL7946450 | 0.77 | RAB9A (0.36) | MEN1KMT2ANPC1SMN1; SMN2LMNA | |
| SCHEMBL8329574 | 0.76 | PTPN11 (0.33) | SMN1; SMN2LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL7955454 | 0.76 | CYP11B2 (0.36) | NPC1ALDH1A1RAB9APOLBTDP1 | |
| Iodide SCHEMBL10859030 | 0.75 | MKNK1 (0.46) | KMT2ARXFP1 | |
| SCHEMBL10742532 | 0.68 | CHEK1 (0.35) | MEN1KMT2APOLB | |
| SCHEMBL10857099 | 0.66 | KDM4E (0.40) | KMT2ANPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL38770 | 0.65 | SMN1; SMN2 (0.68) | NPC1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL30680438 | 0.65 | SMN1; SMN2 (0.68) | NPC1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL7954859 | 0.65 | MKNK1 (0.43) | NPC1SMN1; SMN2ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |