Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957597 | 0.81 | HPGD (0.37) | SMN1; SMN2LMNAADRA1DDHODHRAB9A | |
| SCHEMBL8328584 | 0.79 | MKNK1 (0.44) | — | |
| SCHEMBL7955658 | 0.76 | MEN1 (0.35) | SMN1; SMN2LMNAADRA1DDHODHRAB9A | |
| SCHEMBL7946450 | 0.74 | RAB9A (0.36) | SMN1; SMN2LMNAADRA1DDHODHRAB9A | |
| SCHEMBL7954859 | 0.68 | MKNK1 (0.43) | SMN1; SMN2DHODHRAB9AKDM4EMAP3K14 | |
| SCHEMBL7946519 | 0.68 | PLAU (0.41) | LMNADHODHKDM4EPARP1MAPT | |
| SCHEMBL8330014 | 0.65 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNADHODHRAB9AKDM4E | |
| SCHEMBL38770 | 0.63 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNARAB9AKDM4EPARP1 | |
| SCHEMBL30680438 | 0.63 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNARAB9AKDM4EPARP1 | |
| Hydrochloric Acid SCHEMBL5008498 | 0.62 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNARAB9AKDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | disclosed |