Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631456 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2MAPTUSP2MAPK1TSHR | |
| SCHEMBL7961639 | 0.75 | SMN1; SMN2 (0.70) | HRH3SMN1; SMN2LMNAHSD17B10MAPT | |
| SCHEMBL10684394 | 0.74 | NPC1 (0.62) | SMN1; SMN2MAPTUSP2TSHRALDH1A1 | |
| SCHEMBL8630996 | 0.72 | CHKA (0.44) | SMN1; SMN2MAPTUSP2MAPK1TSHR | |
| Hydrochloric Acid SCHEMBL8632109 | 0.71 | AKR1C3 (0.43) | SMN1; SMN2MAPTUSP2MAPK1TSHR | |
| SCHEMBL7947472 | 0.70 | SMN1; SMN2 (0.43) | HRH3SMN1; SMN2HSD17B10MAPTUSP2 | |
| SCHEMBL7962391 | 0.70 | POLB (0.81) | HRH3SMN1; SMN2LMNAMAPTUSP2 | |
| SCHEMBL7947475 | 0.69 | KMT2A (0.52) | SMN1; SMN2ALDH1A1HPGDPLA2G1BATG4B | |
| SCHEMBL28199807 | 0.68 | MAPT (0.43) | SMN1; SMN2LMNAMAPTMAPK1TSHR | |
| SCHEMBL27463569 | 0.68 | POLB (0.64) | HRH3SMN1; SMN2MAPTHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |