Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7952860 | 0.77 | DRD2 (0.32) | DRD2DRD4APAF1TDP2NSD2 | |
| Hydrochloric Acid SCHEMBL7951045 | 0.76 | APAF1 (0.33) | DRD2DRD4APAF1TDP2NSD2 | |
| SCHEMBL7950407 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL6851818 | 0.69 | CYP1A2 (0.32) | DRD2DRD4APAF1TDP2NSD2 | |
| Hydrochloric Acid SCHEMBL6865428 | 0.69 | CYP1A2 (0.32) | DRD2DRD4APAF1TDP2NSD2 | |
| Hydrochloric Acid SCHEMBL6388088 | 0.69 | DRD2 (0.32) | DRD2DRD4APAF1TDP2NSD2 | |
| SCHEMBL6749148 | 0.68 | DRD2 (0.33) | DRD2DRD4APAF1TDP2NSD2 | |
| Hydrochloric Acid SCHEMBL7632725 | 0.68 | APAF1 (0.33) | APAF1TDP2NSD2HKDC1 | |
| Hydrochloric Acid SCHEMBL7632839 | 0.68 | APAF1 (0.33) | APAF1TDP2NSD2HKDC1 | |
| Hydrochloric Acid SCHEMBL6851450 | 0.68 | TSHR (0.33) | DRD2DRD4APAF1TDP2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268444-B1 | TITANIUM, ZIRCONIUM OR HAFNIUM COMPOUNDS FOR POLYMERIZATION | DOW CHEMICAL COMPANY | 2001-07-31 | — | — | US | claimed |