Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946510 | 0.86 | CYP11B2 (0.42) | CYP11B2KDM4EHSD17B10HTTDYRK1A | |
| SCHEMBL7951763 | 0.78 | MEN1 (0.48) | CYP11B2KDM4EHTTALDH1A1MAPT | |
| SCHEMBL7957240 | 0.78 | MKNK1 (0.39) | CYP11B2KDM4EHSD17B10HTTDYRK1A | |
| SCHEMBL7590017 | 0.78 | CYP11B2 (0.44) | CYP11B2KDM4EHSD17B10HTTDYRK1A | |
| SCHEMBL10743662 | 0.77 | LMNA (0.42) | CYP11B2 | |
| SCHEMBL7954873 | 0.73 | CYP11B2 (0.39) | CYP11B2KDM4ECYP11B1ALDH1A1HPGD | |
| SCHEMBL7946460 | 0.73 | CYP11B2 (0.41) | CYP11B2KDM4ECYP11B1ALDH1A1MAOA | |
| SCHEMBL7961492 | 0.72 | CYP11B2 (0.43) | CYP11B2KDM4EHSD17B10HTTDYRK1A | |
| SCHEMBL7946516 | 0.71 | NPC1 (0.36) | CYP11B2HSD17B10HTTTSHRALDH1A1 | |
| SCHEMBL8568843 | 0.70 | CYP11B2 (0.42) | CYP11B2KDM4EHSD17B10HTTDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| US-4684658-A | Anti-thrombotic ortho-condensed pyrrole derivatives, compositions, and method of use therefor | RHONE-POULENC SANTE (FR) | 1987-08-04 | — | — | US | disclosed |