Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10743662 | 0.89 | LMNA (0.42) | MEN1KMT2AGFERPOLBMKNK1 | |
| SCHEMBL7953609 | 0.87 | MEN1 (0.53) | MEN1KMT2AGFERCYP11B2ALDH1A1 | |
| SCHEMBL7946516 | 0.82 | NPC1 (0.36) | MEN1KMT2AGFERPOLBGPR35 | |
| SCHEMBL7946425 | 0.79 | KDM4E (0.49) | MEN1KMT2AGPR35MKNK1MKNK2 | |
| SCHEMBL7953590 | 0.78 | CYP11B2 (0.44) | CYP11B2KDM4EHTTALDH1A1MAPT | |
| SCHEMBL10736745 | 0.78 | KMT2A (0.44) | MEN1KMT2AGFERPOLBMKNK1 | |
| SCHEMBL7957240 | 0.76 | MKNK1 (0.39) | MEN1KMT2AGFERPOLBMKNK1 | |
| SCHEMBL10742285 | 0.73 | KMO (0.42) | MEN1KMT2AGFERPOLBMKNK1 | |
| SCHEMBL8328659 | 0.73 | GPR35 (0.38) | GPR35MKNK1MKNK2TBXAS1KMO | |
| SCHEMBL8325141 | 0.71 | KDM4E (0.39) | POLBGPR35MKNK1MKNK2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |