Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | CTSE | P14091 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362226 | 0.87 | ALDH1A1 (0.62) | SMN1; SMN2MAPTCYP1A2CYP2D6TSHR | |
| SCHEMBL7366909 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTCYP1A2CYP2D6TSHR | |
| SCHEMBL4678395 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1POLBKDM4E | |
| SCHEMBL29611056 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1POLBKDM4E | |
| SCHEMBL6652831 | 0.83 | CYP1A2 (0.40) | SMN1; SMN2CYP1A2RENCTSDCTSE | |
| SCHEMBL6652835 | 0.83 | CYP1A2 (0.40) | SMN1; SMN2CYP1A2RENCTSDCTSE | |
| SCHEMBL30992257 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTALDH1A1POLBKDM4E | |
| SCHEMBL7361383 | 0.82 | REN (0.63) | RENCTSDCTSECTSK | |
| SCHEMBL4057580 | 0.81 | ATM (0.56) | CTSDCTSK | |
| SCHEMBL4057582 | 0.81 | ATM (0.56) | CTSDCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172064-B1 | METALLOPROTEASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIDIABETIC AGENTS; ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-01-09 | — | — | US | disclosed |