Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956458 | 0.87 | POLB (0.51) | SMN1; SMN2LMNAPOLBKMT2AMEN1 | |
| SCHEMBL7958994 | 0.85 | GFER (0.50) | SMN1; SMN2LMNAPOLBKMT2AMAPT | |
| SCHEMBL7956246 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAKMT2AMEN1CYP1A2 | |
| SCHEMBL7958300 | 0.78 | KMT2A (0.53) | SMN1; SMN2LMNAKMT2AMEN1CYP1A2 | |
| SCHEMBL7947622 | 0.77 | MAPT (0.50) | SMN1; SMN2POLBKMT2AMEN1MAPT | |
| SCHEMBL7956461 | 0.76 | ALDH1A1 (0.54) | SMN1; SMN2LMNAPOLBKMT2AMEN1 | |
| SCHEMBL7958986 | 0.76 | HTR7 (0.51) | SMN1; SMN2KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL7956239 | 0.76 | CYP19A1 (0.46) | SMN1; SMN2LMNAKMT2AMEN1RAB9A | |
| SCHEMBL7956809 | 0.72 | SETDB1 (0.53) | SMN1; SMN2KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL14355762 | 0.69 | HTR6 (0.49) | POLBKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |