Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947608 | 0.87 | MEN1 (0.42) | ALDH1A1HTR1ADRD2GAAF2 | |
| SCHEMBL6429959 | 0.71 | LMNA (0.64) | ALDH1A1GAAPRSS1 | |
| SCHEMBL7947310 | 0.70 | MCOLN3 (0.50) | GAAMMP1NAMPT | |
| SCHEMBL7956560 | 0.69 | KDM4E (0.65) | PANK3POLBHRH1HRH3 | |
| SCHEMBL10677218 | 0.69 | CNR2 (0.47) | ALDH1A1HTR1ADRD2GAAMMP1 | |
| SCHEMBL7956445 | 0.68 | NAMPT (0.52) | PANK3HTR1ADRD2NAMPTROCK2 | |
| SCHEMBL10635190 | 0.68 | CNR2 (0.44) | HTR1ADRD2POLBGAAMMP1 | |
| SCHEMBL7956239 | 0.67 | CYP19A1 (0.46) | GAAHRH1HRH3NAMPT | |
| SCHEMBL7954927 | 0.67 | HRH1 (0.52) | ALDH1A1HTR1AHRH1HRH3 | |
| SCHEMBL7947472 | 0.67 | SMN1; SMN2 (0.43) | ALDH1A1GAAF2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |