Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955329 | 0.83 | NPC1 (0.52) | HPGDKMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL7960109 | 0.82 | ALDH1A1 (0.54) | LMNAALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL7953476 | 0.75 | RECQL (0.61) | HPGDLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL689542 | 0.73 | CYP2C19 (0.66) | HPGDLMNAKMT2AALDH1A1TSHR | |
| SCHEMBL10157126 | 0.73 | HPGD (0.56) | HPGDLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL1709292 | 0.73 | HPGD (0.65) | HPGDLMNAKMT2AALDH1A1HTT | |
| SCHEMBL28853573 | 0.73 | LMNA (0.56) | HPGDLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL5071229 | 0.73 | TGM2 (0.69) | HPGDLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL3231132 | 0.72 | HPGD (0.56) | HPGDLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL17152509 | 0.71 | HPGD (0.51) | HPGDLMNAKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172064-B1 | METALLOPROTEASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIDIABETIC AGENTS; ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-01-09 | — | — | US | disclosed |