Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 3/20 | 0.62 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25329356 | 0.83 | L3MBTL1 (0.43) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL7950622 | 0.78 | ABCC8 (0.73) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| Diazoxide SCHEMBL41255 | 0.77 | ABCC8 (1.00) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| Diazoxide SCHEMBL31112206 | 0.77 | ABCC8 (1.00) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL7950864 | 0.74 | ABCC8 (0.66) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL720640 | 0.74 | ALDH1A1 (0.66) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL7952683 | 0.70 | ABCC8 (0.61) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL30885708 | 0.70 | ABCC8 (0.61) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL16983458 | 0.70 | ALDH1A1 (0.61) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL30885704 | 0.70 | ABCC8 (0.61) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1081633-C | 1,2, 4-benzothiadiazine derivatives, method for preparing same and use thereof | NOVO NORDISK AS (DK) | 2002-03-27 | — | — | CN | disclosed |
| US-6242443-B1 | 1,2,4-benzothiadiazine derivatives, their preparation and use | NOVO NORDISK AIS (DK) | 2001-06-05 | — | — | US | disclosed |
| CN-1222910-A | 1,2, 4-benzothiadiazine derivatives, method for preparing same and use thereof | NOVO NORDISK AS (DK) | 1999-07-14 | — | — | CN | disclosed |