Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 1.00 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.81 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.81 |
| ▸ | ATM | Q13315 | 3/20 | 0.81 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.81 |
| ▸ | CCR6 | P51684 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.67 |
| ▸ | HTT | P42858 | 6/20 | 0.67 |
| ▸ | APAF1 | O14727 | 3/20 | 0.67 |
| ▸ | MITF | O75030 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | CDC25A | P30304 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14669410 | 0.90 | HSP90AA1 (0.82) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL9702171 | 0.90 | HKDC1 (1.00) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL19625589 | 0.88 | HSP90AA1 (0.78) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL16296749 | 0.88 | HSP90AA1 (0.78) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL21779251 | 0.86 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL18425602 | 0.84 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL16297016 | 0.80 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL6190569 | 0.79 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL31087717 | 0.79 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 | |
| SCHEMBL16296885 | 0.79 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1KMT2AHKDC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220128562-A1 | BIOMARKERS PREDICTIVE OF CANCER CELL RESPONSE TO ML329 OR A DERIVATIVE THEREOF | UNIVERSITY OF KANSAS | 2022-04-28 | — | — | US | disclosed |
| US-20170334842-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-20170334842-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-20170334842-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-9745261-B2 | Inhibitors of the MITF molecular pathway | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745261-B2 | Inhibitors of the MITF molecular pathway | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745261-B2 | Inhibitors of the MITF molecular pathway | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160130222-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | THE BROAD INSTITUTE, INC. | 2016-05-12 | — | — | US | disclosed |
| US-20160130222-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | THE BROAD INSTITUTE, INC. | 2016-05-12 | — | — | US | disclosed |
| US-20160130222-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | THE BROAD INSTITUTE, INC. | 2016-05-12 | — | — | US | disclosed |
| EP-3007688-A2 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | The General Hospital Corporation (US) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014201016-A2 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-12-18 | — | — | WO | disclosed |
| WO-2014201016-A2 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-12-18 | — | — | WO | disclosed |
| US-6174918-B1 | INHIBITING TUMOR CELL GROWTH SENSITIVE TO NAPHTHOQUINONE DERIVATIVE IN MAMMAL BY ADMINISTERING 2,3-DISUBSTITUTED NAPHTHOQUINONE COMPOUND | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-16 | — | — | US | disclosed |
| CN-1206403-A | Naphthoquinone antitumor compounds and methods | UNIV NORTH CAROLINA CHAPEL HILL (US) | 1999-01-27 | — | — | CN | disclosed |
| US-5789431-A | INHIBITING CELL TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-08-04 | — | — | US | disclosed |
| WO-1997030022-A1 | NAPHTHOQUINONE ANTITUMOR COMPOUND AND METHOD | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130222-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | MITF, TFEB, TYR | HSP90AA1 2413/4885HSP90AB1 1684/4885KMT2A 2018/4885 |
| US-20170334842-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | MITF, TFEB, TYR | HSP90AA1 2375/4885HSP90AB1 1696/4885KMT2A 2146/4885 |
| US-20220128562-A1 | BIOMARKERS PREDICTIVE OF CANCER CELL RESPONSE TO ML329 OR A DERIVATIVE THEREOF | NQO1, KEAP1, NFE2L2 | HSP90AA1 952/4885HSP90AB1 733/4885KMT2A 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.