Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957585 | 0.83 | KMT2A (0.48) | DRD2LMNAKMT2APOLBHTT | |
| SCHEMBL7957071 | 0.82 | DRD2 (0.54) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL7949576 | 0.81 | DRD2 (0.48) | DRD2DRD4LMNAKMT2APOLB | |
| SCHEMBL7067307 | 0.80 | DRD2 (0.60) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL9032338 | 0.80 | SLC6A4 (0.70) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL7960244 | 0.80 | DRD2 (0.62) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL7961377 | 0.79 | DRD2 (0.58) | DRD2SLC6A4HRH3DRD4KMT2A | |
| SCHEMBL6710735 | 0.79 | SLC6A4 (0.68) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL6788939 | 0.78 | DRD2 (0.50) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL9323878 | 0.77 | SLC6A4 (0.74) | DRD2SLC6A4HRH3HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |