Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949576 | 0.91 | DRD2 (0.48) | KMT2AHTR1ADRD2CACNA1GLMNA | |
| SCHEMBL7957074 | 0.83 | DRD2 (0.58) | KMT2ADRD2LMNAPOLBHTT | |
| SCHEMBL7957582 | 0.81 | OPRL1 (0.45) | ADRA1BHTR1ADRD2CCR2ADRA1D | |
| SCHEMBL7959651 | 0.81 | ALDH1A1 (0.43) | KMT2ADRD2POLBHTTCCR2 | |
| SCHEMBL7960163 | 0.80 | DRD2 (0.62) | DRD2PRCPCCR2 | |
| SCHEMBL7961179 | 0.79 | DRD2 (0.47) | DRD2CACNA1GPOLBCCR2OPRL1 | |
| SCHEMBL7957634 | 0.79 | ALDH1A1 (0.50) | DRD2CACNA1GPOLBHTT | |
| SCHEMBL7949583 | 0.79 | DRD2 (0.54) | DRD2CACNA1GPRCPPOLB | |
| SCHEMBL7961467 | 0.79 | HTR4 (0.48) | ADRA1BHTR1ADRD2POLB | |
| SCHEMBL7961258 | 0.78 | POLB (0.44) | KMT2AHTR1ADRD2CACNA1GPRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |