Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957582 | 0.85 | OPRL1 (0.45) | DRD2SLC6A4DRD4CCR2ADRA1A | |
| SCHEMBL7067307 | 0.83 | DRD2 (0.60) | DRD2SLC6A4HRH3KDM4EHSD17B10 | |
| SCHEMBL7949574 | 0.83 | DRD2 (0.46) | DRD2SLC6A4DRD4CCR2HTR1A | |
| SCHEMBL7957074 | 0.82 | DRD2 (0.58) | DRD2SLC6A4HRH3KDM4EHSD17B10 | |
| SCHEMBL7961375 | 0.81 | SLC6A4 (0.54) | DRD2SLC6A4HRH3DRD4ADRA1A | |
| SCHEMBL7959852 | 0.78 | KDM4E (0.47) | DRD2SLC6A4KDM4EHSD17B10ADRA1A | |
| SCHEMBL7967897 | 0.78 | GLA (0.44) | DRD2ADRA1ADRD3 | |
| SCHEMBL6848950 | 0.77 | DRD2 (0.55) | DRD2SLC6A4HRH3KDM4EHSD17B10 | |
| SCHEMBL7957632 | 0.77 | CCR2 (0.42) | DRD2DRD4CCR2DRD3 | |
| SCHEMBL7961177 | 0.77 | OPRL1 (0.44) | DRD2CCR2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |