Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | TNF | P01375 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961467 | 0.84 | HTR4 (0.48) | DRD2HTR4KDM4EALDH1A1MAPT | |
| SCHEMBL7957657 | 0.82 | DRD2 (0.49) | DRD2HTR4CNR1KDM4EALDH1A1 | |
| SCHEMBL10595036 | 0.81 | SLC18A3 (0.61) | DRD2SLC6A4HTR4MEN1KMT2A | |
| SCHEMBL8287642 | 0.80 | DRD4 (0.67) | HTR4 | |
| SCHEMBL8286387 | 0.80 | HRH3 (0.55) | TNFHRH3HTR4CNR1 | |
| SCHEMBL7959172 | 0.80 | DRD2 (0.62) | DRD2SLC6A4TNFHRH3HTR4 | |
| SCHEMBL7957074 | 0.80 | DRD2 (0.58) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL7067307 | 0.78 | DRD2 (0.60) | DRD2SLC6A4HRH3HTR1DHTR1B | |
| SCHEMBL7961389 | 0.78 | NPY1R (0.50) | DRD2HTR4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL7957439 | 0.76 | DRD2 (0.55) | DRD2HTR4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |