Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.51 |
| ▸ | PARP1 | P09874 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949039 | 0.85 | SIGMAR1 (0.53) | SIGMAR1PARP1HTR1ADRD2 | |
| SCHEMBL8571894 | 0.84 | SIGMAR1 (0.51) | SIGMAR1PARP1HTR1ADRD2 | |
| SCHEMBL7961180 | 0.78 | DRD2 (0.46) | SIGMAR1PARP1HTR1ADRD2 | |
| SCHEMBL7964099 | 0.76 | HPGD (0.53) | SIGMAR1PARP1HTR1A | |
| SCHEMBL7949425 | 0.76 | LMNA (0.52) | SIGMAR1PARP1DRD2 | |
| SCHEMBL7949533 | 0.75 | GAA (0.50) | SIGMAR1PARP1 | |
| SCHEMBL7957285 | 0.75 | SIGMAR1 (0.53) | SIGMAR1PARP1DRD2 | |
| SCHEMBL7959188 | 0.75 | HPGD (0.51) | SIGMAR1HTR1A | |
| SCHEMBL7959347 | 0.74 | LMNA (0.45) | SIGMAR1PARP1DRD2 | |
| SCHEMBL7959719 | 0.73 | SIGMAR1 (0.55) | SIGMAR1PARP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |