Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949032 | 0.99 | SIGMAR1 (0.52) | SIGMAR1SMN1; SMN2PARP1ARRAB9A | |
| SCHEMBL7949039 | 0.81 | SIGMAR1 (0.53) | SIGMAR1SMN1; SMN2PARP1DRD2HTR1A | |
| SCHEMBL7963618 | 0.79 | SIGMAR1 (0.51) | SIGMAR1SMN1; SMN2DRD2HTR1A | |
| SCHEMBL7949350 | 0.78 | SIGMAR1 (0.50) | SIGMAR1SMN1; SMN2DRD2HTR1A | |
| SCHEMBL7963783 | 0.77 | DRD2 (0.48) | SIGMAR1SMN1; SMN2PARP1ARRAB9A | |
| SCHEMBL7960226 | 0.77 | DRD2 (0.47) | SIGMAR1SMN1; SMN2PARP1ARRAB9A | |
| SCHEMBL9375288 | 0.72 | SIGMAR1 (0.92) | SIGMAR1PARP1DRD2HTR1A | |
| SCHEMBL7949425 | 0.71 | LMNA (0.52) | SIGMAR1SMN1; SMN2PARP1DRD2 | |
| SCHEMBL11938943 | 0.71 | SIGMAR1 (0.65) | SIGMAR1DRD2HTR1APPARGPPARA | |
| SCHEMBL6626009 | 0.71 | SIGMAR1 (0.65) | SIGMAR1PARP1DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |