Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
| ▸ | DRD3 | P35462 | 11/20 | 0.48 |
| ▸ | DRD2 | P14416 | 10/20 | 0.48 |
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 7/20 | 0.48 |
| ▸ | DRD1 | P21728 | 5/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.48 |
| ▸ | DRD5 | P21918 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949350 | 0.99 | SIGMAR1 (0.50) | SIGMAR1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7949455 | 0.89 | MAPK1 (0.46) | SIGMAR1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7957460 | 0.89 | HTR1A (0.48) | SIGMAR1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7957292 | 0.88 | SIGMAR1 (0.52) | SIGMAR1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7949256 | 0.88 | THRB (0.47) | SIGMAR1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7963783 | 0.82 | DRD2 (0.48) | SIGMAR1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7960226 | 0.81 | DRD2 (0.47) | SIGMAR1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL7957237 | 0.79 | SIGMAR1 (0.53) | SIGMAR1DRD2HTR1ASMN1; SMN2 | |
| SCHEMBL7949032 | 0.78 | SIGMAR1 (0.52) | SIGMAR1DRD2HTR1ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11637430 | 0.73 | KDM4E (0.67) | SIGMAR1DRD3DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |