Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.58 |
| ▸ | HTR1A | P08908 | 8/20 | 0.58 |
| ▸ | DRD2 | P14416 | 8/20 | 0.58 |
| ▸ | DRD4 | P21917 | 8/20 | 0.58 |
| ▸ | HTR2A | P28223 | 8/20 | 0.58 |
| ▸ | HTR2C | P28335 | 8/20 | 0.58 |
| ▸ | HTR7 | P34969 | 8/20 | 0.58 |
| ▸ | HTR1D | P28221 | 7/20 | 0.58 |
| ▸ | HRH2 | P25021 | 6/20 | 0.58 |
| ▸ | HRH1 | P35367 | 5/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.54 |
| ▸ | DRD3 | P35462 | 7/20 | 0.54 |
| ▸ | HTR2B | P41595 | 7/20 | 0.54 |
| ▸ | DRD1 | P21728 | 6/20 | 0.54 |
| ▸ | DRD5 | P21918 | 6/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.54 |
| ▸ | HTR6 | P50406 | 6/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959210 | 0.88 | DRD2 (0.45) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL7957371 | 0.86 | LMNA (0.52) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL7963703 | 0.84 | HSD11B1 (0.41) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL7959708 | 0.84 | DRD2 (0.55) | OPRM1HTR1ADRD2DRD4HTR2A | |
| SCHEMBL7959714 | 0.83 | GAA (0.50) | HTR1ADRD2DRD4HTR2AHTR2C | |
| SCHEMBL7960241 | 0.81 | CCR1 (0.48) | OPRM1HTR1ADRD2DRD4HTR2A | |
| SCHEMBL7961346 | 0.80 | HSD11B1 (0.50) | HTR1ADRD2HTR2AHTR2CHRH1 | |
| SCHEMBL7957576 | 0.80 | GAA (0.49) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL14282239 | 0.80 | OPRM1 (0.76) | OPRM1OPRK1HTR1ADRD2DRD4 | |
| SCHEMBL7957105 | 0.79 | DRD2 (0.46) | HTR1ADRD2DRD4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |