Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957105 | 0.84 | DRD2 (0.46) | HSD11B1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7957541 | 0.84 | OPRM1 (0.58) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7963844 | 0.81 | LMNA (0.45) | HSD11B1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7959210 | 0.81 | DRD2 (0.45) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7959533 | 0.81 | DRD2 (0.48) | HSD11B1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7959113 | 0.80 | L3MBTL1 (0.41) | HSD11B1HTR1AHTR2AHTR2CL3MBTL1 | |
| SCHEMBL7957371 | 0.79 | LMNA (0.52) | HSD11B1OPRM1DRD2HTR1AHTR2A | |
| SCHEMBL7960165 | 0.79 | PKM (0.52) | HSD11B1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7959708 | 0.78 | DRD2 (0.55) | HSD11B1OPRM1DRD2HTR1AHTR2A | |
| SCHEMBL7963975 | 0.77 | L3MBTL1 (0.39) | HSD11B1HTR1AHTR2AHTR2CL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |