SCHEMBL7957634

SCHEMBL7957634

Cc1cc(Cl)ccc1C1CCN(CCCC(=O)NN)CC1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
DRD2 P14416 8/20 0.49
DRD4 P21917 4/20 0.49
DRD3 P35462 3/20 0.49
POLB P06746 2/20 0.44
CACNA1G O43497 4/20 0.43
HTT P42858 1/20 0.43
HSD17B10 Q99714 1/20 0.43
PROKR1 Q8TCW9 1/20 0.43
MCHR1 Q99705 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7961179 0.87 DRD2 (0.47) ALDH1A1DRD2DRD4DRD3POLB
SCHEMBL7957632 0.83 CCR2 (0.42) DRD2DRD4DRD3POLBPROKR1
SCHEMBL7961389 0.82 NPY1R (0.50) ALDH1A1DRD2DRD4DRD3HSD17B10
SCHEMBL7949583 0.82 DRD2 (0.54) ALDH1A1DRD2DRD4DRD3POLB
SCHEMBL7960163 0.81 DRD2 (0.62) DRD2DRD4DRD3MCHR1
SCHEMBL7949576 0.80 DRD2 (0.48) ALDH1A1DRD2DRD4DRD3POLB
SCHEMBL7957585 0.79 KMT2A (0.48) DRD2POLBCACNA1GHTT
SCHEMBL7964044 0.78 DRD2 (0.53) ALDH1A1DRD2DRD4DRD3
SCHEMBL7957652 0.76 DRD2 (0.55) ALDH1A1DRD2DRD4DRD3POLB
SCHEMBL7964065 0.76 DRD2 (0.53) DRD2DRD4DRD3MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187774-B1 N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2001-02-13 US disclosed
EP-0885883-A1 FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-12-23 EP disclosed