Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961177 | 0.88 | OPRL1 (0.44) | CCR2DRD2 | |
| SCHEMBL7949578 | 0.83 | DRD2 (0.46) | CCR2DRD2DRD3 | |
| SCHEMBL7957634 | 0.83 | ALDH1A1 (0.50) | DRD2DRD4DRD3PROKR1POLB | |
| SCHEMBL7960161 | 0.83 | CCR2 (0.53) | CCR2DRD2DRD4DRD3 | |
| SCHEMBL7949574 | 0.81 | DRD2 (0.46) | CCR2DRD2DRD4DRD3 | |
| SCHEMBL7957582 | 0.81 | OPRL1 (0.45) | CCR2DRD2DRD4DRD3CCR3 | |
| SCHEMBL7964042 | 0.79 | DRD2 (0.46) | DRD2DRD4DRD3 | |
| SCHEMBL7957650 | 0.78 | ADRA1A (0.56) | DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL7964064 | 0.78 | CCR2 (0.48) | CCR2DRD2DRD3 | |
| SCHEMBL7961256 | 0.78 | CCR2 (0.39) | CCR2DRD2CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |