Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970812 | 0.87 | CYP1A2 (0.48) | RAB9AGAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7969082 | 0.86 | RAB9A (0.38) | RAB9AGAANPC1CLK1CYP1A2 | |
| SCHEMBL7969086 | 0.85 | RAB9A (0.38) | RAB9AGAANPC1CLK1CYP1A2 | |
| SCHEMBL7967851 | 0.85 | CYP1A2 (0.45) | CYP1A2CYP3A4CYP2C9HPGDOPRM1 | |
| SCHEMBL7968921 | 0.85 | OPRD1 (0.60) | CYP1A2CYP3A4CYP2C9HPGDOPRM1 | |
| SCHEMBL7967499 | 0.84 | RAB9A (0.40) | RAB9AGAANPC1CLK1CYP1A2 | |
| SCHEMBL7973908 | 0.78 | RAB9A (0.41) | RAB9AGAANPC1CLK1CYP3A4 | |
| SCHEMBL7973713 | 0.77 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C9HPGDOPRM1 | |
| SCHEMBL7971327 | 0.76 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C9HPGDOPRM1 | |
| SCHEMBL7971356 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200978-B1 | FOR PREVENTING OR TREATING INFLAMMATORY DISEASES SUCH AS ARTHRITIS, PSORIASIS, ASTHMA, OR INFLAMMATORY BOWEL DISEASE, DISORDERS OF RESPIRATORY FUNCTION, GASTROINTESTINAL DISORDERS SUCH AS FUNCTIONAL BOWEL DISEASE, AS ANALGESICS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |