Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947463 | 0.83 | HRH3 (0.61) | HRH3HRH1ITGB3ITGA2BHRH2 | |
| SCHEMBL13764324 | 0.81 | APP (0.61) | APPRXRARXRBCA12CA9 | |
| SCHEMBL27037838 | 0.81 | APP (0.61) | APPRXRARXRBMAPTCA12 | |
| SCHEMBL7958198 | 0.80 | CCR5 (0.52) | F10HRH3HRH1 | |
| SCHEMBL4676358 | 0.79 | ITGB3 (0.43) | F10HRH3HRH1ITGB3ITGA2B | |
| SCHEMBL4676367 | 0.78 | ADRB2 (0.60) | — | |
| SCHEMBL7958587 | 0.76 | POLB (0.56) | MAPT | |
| SCHEMBL2399080 | 0.76 | APP (0.80) | APPRXRARXRBCA12CA9 | |
| SCHEMBL7958206 | 0.73 | CCR5 (0.50) | F10HRH3HRH1 | |
| SCHEMBL7332462 | 0.72 | GRM5 (0.47) | F10HRH3HRH1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |