Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | NCF1 | P14598 | 1/20 | 0.60 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.51 |
| ▸ | HTR3B | O95264 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 4/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335477 | 0.85 | LTA4H (0.64) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4676358 | 0.84 | ITGB3 (0.43) | LTA4HFGFR1 | |
| Hydrochloric Acid SCHEMBL2156238 | 0.84 | LTA4H (0.62) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4674253 | 0.83 | HTR6 (0.59) | ADRB2NCF1PLD1ADRB1HTR3E | |
| SCHEMBL12916421 | 0.82 | ADRB1 (0.65) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL381355 | 0.82 | PRMT5 (0.58) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5230479 | 0.80 | LTA4H (0.57) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7947463 | 0.79 | HRH3 (0.61) | — | |
| SCHEMBL7958205 | 0.78 | F10 (0.53) | — | |
| SCHEMBL4674747 | 0.77 | CYP1A2 (0.54) | ADRB2NCF1PLD1ADRB1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |