Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LIG1 | P18858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21818563 | 0.82 | ALOX5 (0.40) | LMNAPKMALOX15ALOX5ALDH1A1 | |
| SCHEMBL7967862 | 0.77 | ALOX5 (0.41) | LMNAALOX15ALOX5NPSR1ALDH1A1 | |
| SCHEMBL31466638 | 0.75 | KDM5A (0.39) | KDM4E | |
| SCHEMBL26131329 | 0.74 | KDM4E (0.42) | LMNAALOX15ALOX5ALDH1A1KDM4E | |
| SCHEMBL30479629 | 0.74 | HTR1A (0.35) | LMNAPKMKDM4EBRD4 | |
| SCHEMBL4478323 | 0.74 | HTR1A (0.35) | LMNAPKMKDM4EBRD4 | |
| SCHEMBL16195591 | 0.74 | ALOX5 (0.35) | ALOX15ALOX5ALDH1A1KDM4ECREBBP | |
| SCHEMBL783714 | 0.73 | LMNA (0.59) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL672668 | 0.71 | LMNA (0.44) | LMNAPKMALOX15NPSR1ALDH1A1 | |
| SCHEMBL1340046 | 0.70 | ALOX5 (0.40) | ALOX15ALOX5NPSR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009127-A1 | BENZOXAZINE DERIVATIVES AND THEIR THERAPEUTIC USE | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |