SCHEMBL7958303

SCHEMBL7958303

Cc1ccccc1S(=O)(=O)NCc1ccc(N2CCN(c3ccncc3)CC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 1/20 0.53
SMN1; SMN2 Q16637 5/20 0.52
HTT P42858 4/20 0.52
GAA P10253 1/20 0.52
NR2F2 P24468 3/20 0.50
ALDH1A1 P00352 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
RAB9A P51151 3/20 0.48
NPC1 O15118 2/20 0.47
NOD2 Q9HC29 1/20 0.47
POLB P06746 3/20 0.47
KMT2A Q03164 2/20 0.47
LMNA P02545 3/20 0.46
MEN1 O00255 1/20 0.45
P2RX7 Q99572 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7956456 0.87 RAB9A (0.49) SMN1; SMN2GAANR2F2ALDH1A1L3MBTL1
SCHEMBL7958982 0.85 POLB (0.60) SMN1; SMN2HTTGAANR2F2ALDH1A1
SCHEMBL11174344 0.85 SMN1; SMN2 (0.69) SMN1; SMN2HTTNR2F2ALDH1A1L3MBTL1
SCHEMBL7956237 0.83 GAA (0.44) SMN1; SMN2GAANR2F2ALDH1A1L3MBTL1
SCHEMBL7956813 0.79 GAA (0.50) SMN1; SMN2HTTGAAL3MBTL1POLB
SCHEMBL407668 0.76 CA12 (0.61) ALDH1A1L3MBTL1POLBLMNA
SCHEMBL7956461 0.76 ALDH1A1 (0.54) SMN1; SMN2HTTNR2F2ALDH1A1RAB9A
SCHEMBL7958990 0.75 ALDH1A1 (0.60) SMN1; SMN2HTTNR2F2ALDH1A1RAB9A
SCHEMBL27083314 0.74 POLB (0.61) SMN1; SMN2HTTGAANR2F2ALDH1A1
SCHEMBL14623888 0.74 CNR1 (0.58) NR3C2GAAALDH1A1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313127-B1 FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS ZENECA LIMITED (GB) 2001-11-06 US disclosed