Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956456 | 0.84 | RAB9A (0.49) | GAALMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7958303 | 0.83 | NR3C2 (0.53) | GAALMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7947307 | 0.83 | SLC22A12 (0.51) | GAALMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL7958982 | 0.80 | POLB (0.60) | GAALMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7956244 | 0.80 | CYP19A1 (0.65) | LMNASMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL6985668 | 0.75 | KMT2A (0.62) | SMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL7956813 | 0.74 | GAA (0.50) | GAALMNASMN1; SMN2KDM4EPOLB | |
| SCHEMBL7956461 | 0.73 | ALDH1A1 (0.54) | LMNASMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL7958990 | 0.70 | ALDH1A1 (0.60) | LMNASMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL12078320 | 0.70 | NAMPT (0.69) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |