Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958937 | 0.89 | PKM (0.52) | LMNASHMT2GAAPKMSMN1; SMN2 | |
| SCHEMBL7949039 | 0.85 | SIGMAR1 (0.53) | GAAPKMSMN1; SMN2HPGDPARP1 | |
| SCHEMBL7949425 | 0.85 | LMNA (0.52) | LMNASHMT2GAAPKMSMN1; SMN2 | |
| SCHEMBL7959347 | 0.83 | LMNA (0.45) | LMNASHMT2GAASMN1; SMN2HPGD | |
| SCHEMBL7949533 | 0.83 | GAA (0.50) | GAAPKMSMN1; SMN2HPGDPOLB | |
| SCHEMBL7961207 | 0.83 | POLB (0.44) | LMNASHMT2GAASMN1; SMN2POLB | |
| SCHEMBL7957285 | 0.81 | SIGMAR1 (0.53) | LMNAPOLBPARP1SIGMAR1 | |
| SCHEMBL7959202 | 0.81 | GAA (0.41) | LMNASHMT2GAASMN1; SMN2HPGD | |
| SCHEMBL7963975 | 0.81 | L3MBTL1 (0.39) | LMNASHMT2GAAPKMSMN1; SMN2 | |
| SCHEMBL7964099 | 0.78 | HPGD (0.53) | LMNAHPGDPOLBPARP1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |