Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.46 |
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.46 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7959572 | 1.00 | SIGMAR1 (0.49) | SIGMAR1DRD4HTR2CHTR1AHTR7 | |
| SCHEMBL7963930 | 0.86 | SIGMAR1 (0.53) | SIGMAR1DRD4HTR1AHTR7PTGS1 | |
| SCHEMBL7959679 | 0.83 | DRD3 (0.49) | SIGMAR1DRD4HTR2CHTR1AHTR7 | |
| SCHEMBL7963943 | 0.83 | MAPT (0.50) | SIGMAR1HTR1AHTR7PTGS1PTGS2 | |
| SCHEMBL7959536 | 0.78 | SIGMAR1 (0.52) | SIGMAR1DRD4HTR2CHTR1AHTR7 | |
| SCHEMBL5774661 | 0.76 | SIGMAR1 (0.56) | SIGMAR1DRD4HTR2CHTR1AHTR7 | |
| SCHEMBL7959137 | 0.76 | SIGMAR1 (0.53) | SIGMAR1DRD4HTR2CHTR1AHTR7 | |
| Fumaric Acid SCHEMBL5773660 | 0.73 | DRD2 (0.45) | SIGMAR1DRD4HTR2CHTR1AHTR7 | |
| Maleic Acid SCHEMBL5773645 | 0.73 | DRD2 (0.45) | SIGMAR1DRD4HTR2CHTR1AHTR7 | |
| SCHEMBL5772655 | 0.72 | HTR1A (0.51) | SIGMAR1DRD4HTR2CHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |