Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975606 | 0.99 | BRD4 (0.37) | BRD4SIRT2SIRT1ATRCNR1 | |
| SCHEMBL10140034 | 0.85 | CNR1 (0.39) | BRD4SIRT2SIRT1ATRCNR1 | |
| SCHEMBL7960886 | 0.84 | CNR1 (0.38) | BRD4SIRT2SIRT1ATRCNR1 | |
| SCHEMBL7972878 | 0.84 | HPSE (0.38) | BRD4RAB9ANPC1CHEK2SMN1; SMN2 | |
| SCHEMBL7975112 | 0.78 | F9 (0.47) | BRD4CNR1RAB9ANPC1CHEK2 | |
| SCHEMBL10140037 | 0.77 | CYP2C9 (0.41) | BRD4SIRT2SIRT1ATRACHE | |
| SCHEMBL20307729 | 0.74 | F9 (0.40) | RAB9ANPC1CHEK2SMN1; SMN2 | |
| SCHEMBL7969308 | 0.73 | TSPO (0.37) | BRD4SIRT2SIRT1CHEK2 | |
| SCHEMBL7980011 | 0.72 | CHEK2 (0.38) | BRD4ATRRAB9ANPC1CHEK2 | |
| SCHEMBL7960749 | 0.72 | HDAC3 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |