Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 3/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975112 | 0.80 | F9 (0.47) | CHEK2BRD4 | |
| SCHEMBL20307729 | 0.76 | F9 (0.40) | CHEK2KDRITK | |
| SCHEMBL7960271 | 0.76 | BRD4 (0.36) | TSPOCHEK2EGFRBRD4 | |
| SCHEMBL7972878 | 0.76 | HPSE (0.38) | CHEK2KDREGFRBRD4 | |
| SCHEMBL7975606 | 0.74 | BRD4 (0.37) | CHEK2SIRT2SIRT1BRD4 | |
| SCHEMBL10140040 | 0.74 | CHEK2 (0.34) | TSPOCHEK2EGFRSIRT2SIRT1 | |
| SCHEMBL7973068 | 0.73 | CHEK2 (0.39) | CHEK2SYKITK | |
| SCHEMBL7960176 | 0.73 | BRD4 (0.36) | CHEK2SIRT2SIRT1BRD4 | |
| SCHEMBL7972241 | 0.72 | F9 (0.41) | CHEK2SIRT2SIRT1SIRT3BRD4 | |
| SCHEMBL7977818 | 0.71 | F9 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |