Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | DRD3 | P35462 | 8/20 | 0.43 |
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 3/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949134 | 0.89 | SIGMAR1 (0.48) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL7949605 | 0.86 | DRD2 (0.48) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL7959798 | 0.85 | DRD2 (0.47) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL5772376 | 0.81 | HTR1A (0.43) | DRD2DRD3HTR1AHTR2ADRD4 | |
| Hydrochloric Acid SCHEMBL7959877 | 0.81 | DRD3 (0.51) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL7965107 | 0.75 | SIGMAR1 (0.51) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL7963959 | 0.75 | MAPT (0.44) | SIGMAR1ADRA1DADRA1AADRA1BHRH1 | |
| SCHEMBL7963539 | 0.74 | SIGMAR1 (0.50) | DRD2DRD3HTR1AHTR2ADRD4 | |
| Hydrochloric Acid SCHEMBL7960917 | 0.73 | SIGMAR1 (0.49) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL7959558 | 0.72 | SIGMAR1 (0.47) | DRD2DRD3HTR1AHTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |