Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957224 | 1.00 | MMP1 (0.38) | MMP1MMP13ECE1MMP3BACE1 | |
| SCHEMBL7960470 | 1.00 | MMP1 (0.38) | MMP1MMP13ECE1MMP3BACE1 | |
| SCHEMBL7957364 | 0.93 | MMP1 (0.39) | MMP1MMP13ECE1MMP3FPR2 | |
| SCHEMBL7827988 | 0.93 | MMP1 (0.39) | MMP1MMP13ECE1MMP3FPR2 | |
| SCHEMBL7946782 | 0.91 | MMP1 (0.36) | MMP1MMP13ECE1MMP3BACE1 | |
| SCHEMBL7946779 | 0.91 | MMP1 (0.36) | MMP1MMP13ECE1MMP3BACE1 | |
| SCHEMBL7848201 | 0.90 | L3MBTL1 (0.36) | MMP1MMP13MMP3BACE1CTSK | |
| SCHEMBL7946527 | 0.89 | MMP1 (0.43) | MMP1MMP13MMP3APPADAM17 | |
| SCHEMBL7946524 | 0.89 | MMP1 (0.43) | MMP1MMP13MMP3APPADAM17 | |
| SCHEMBL7838763 | 0.86 | MMP3 (0.36) | MMP1MMP13MMP3FPR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |