Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 10/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961303 | 0.85 | F10 (0.54) | F10F2ELANEHRH1HRH3 | |
| SCHEMBL8633873 | 0.83 | ITGB3 (0.53) | F10HRH1HRH3 | |
| SCHEMBL7956714 | 0.78 | ACACB (0.60) | F10F2HRH1HRH3 | |
| SCHEMBL7947657 | 0.78 | HTR2C (0.47) | HTR2CHTR2BHTR1AADRA2AADRA2B | |
| SCHEMBL20595486 | 0.75 | HTR2C (0.42) | F10HTR2CHTR2BHRH3 | |
| SCHEMBL31108082 | 0.75 | HTR2C (0.42) | F10HTR2CHTR2BHRH3 | |
| SCHEMBL7956699 | 0.74 | ACACB (0.48) | F10 | |
| SCHEMBL7955317 | 0.72 | HRH1 (0.47) | HRH1HRH3 | |
| SCHEMBL8620385 | 0.72 | GRIN2B (0.50) | F10HTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL2636637 | 0.72 | SMN1; SMN2 (0.46) | HTR2CHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |