Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 6/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974351 | 0.96 | TP53 (0.51) | TP53TSHRPLA2G4BPKMRARB | |
| SCHEMBL7961494 | 0.89 | MAPT (0.56) | HTTL3MBTL1NPC1POLBRAB9A | |
| SCHEMBL7971231 | 0.86 | GPR119 (0.53) | L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7972638 | 0.85 | MAPT (0.55) | HTTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7971192 | 0.83 | GPR119 (0.57) | L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7974717 | 0.82 | PKM (0.48) | TP53TSHRPLA2G4BPKMRARB | |
| SCHEMBL7972769 | 0.82 | MAPT (0.47) | L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7973158 | 0.81 | MEN1 (0.46) | TP53TSHRPLA2G4BPKMRARB | |
| SCHEMBL7977465 | 0.79 | TP53 (0.49) | TP53TSHRPLA2G4BPKMRARB | |
| SCHEMBL7971292 | 0.78 | HRH3 (0.41) | TP53L3MBTL1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326369-B1 | ALZHEIMER'S DISEASE | TAKEDA CHEMICALS INDUSTRIES, LTD. (JP) | 2001-12-04 | — | — | US | disclosed |
| EP-0968164-A1 | BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998033758-A1 | BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-08-06 | — | — | WO | disclosed |