Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972638 | 0.90 | MAPT (0.55) | MAPTL3MBTL1TDP1ALDH1A1GAA | |
| SCHEMBL7974351 | 0.86 | TP53 (0.51) | L3MBTL1TDP1GAAKMT2A | |
| SCHEMBL7961494 | 0.86 | MAPT (0.56) | MAPTL3MBTL1TDP1ALDH1A1GAA | |
| SCHEMBL7977603 | 0.84 | L3MBTL1 (0.47) | MAPTKCNH2HRH3L3MBTL1TDP1 | |
| SCHEMBL7971192 | 0.83 | GPR119 (0.57) | L3MBTL1TBXAS1ALDH1A1GAA | |
| SCHEMBL7961401 | 0.82 | TP53 (0.49) | L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7974462 | 0.82 | MAPT (0.47) | MAPTKCNH2HRH3L3MBTL1TDP1 | |
| SCHEMBL7971231 | 0.79 | GPR119 (0.53) | MAPTL3MBTL1TBXAS1ALDH1A1GAA | |
| SCHEMBL7971292 | 0.78 | HRH3 (0.41) | HRH3L3MBTL1GAAKMT2A | |
| SCHEMBL7961432 | 0.78 | HPGD (0.54) | MAPTHRH3L3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326369-B1 | ALZHEIMER'S DISEASE | TAKEDA CHEMICALS INDUSTRIES, LTD. (JP) | 2001-12-04 | — | — | US | disclosed |
| EP-0968164-A1 | BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998033758-A1 | BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-08-06 | — | — | WO | disclosed |